Efficacy of shitei-to, a traditional Chinese medicine formulation, against convulsions in mice.

Abstract

The anticonvulsant effects of Shitei-To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had no effect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.

• Authors: E Minami, H Shibata, Y Nunoura, M Nomoto, T Fukuda
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 27 Issue 1 Pg. 107-15 ( 1999) ISSN: 0192-415X [Print] Singapore
• PMID: 10354822 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Convulsants
• Drugs, Chinese Herbal
• shitei-to
• Strychnine
• Pentylenetetrazole
• Bicuculline

Topics

• Animals
• Anticonvulsants (therapeutic use)
• Bicuculline
• Convulsants
• Drugs, Chinese Herbal (therapeutic use)
• Electroshock
• Male
• Mice
• Mice, Inbred Strains
• Pentylenetetrazole
• Seizures (chemically induced, drug therapy)
• Strychnine