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Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation: a clinicopathological correlation with angiography and serial estimation of serum levels of renin, eosinophil cationic protein and interleukin 5.

Abstract
We present a case of angiolymphoid hyperplasia with eosinophilia (ALHE) affecting the auricular area of a 31-year-old man, which clinically mimicked arteriovenous malformation (AVM). The histology and laboratory data distinctively revealed ALHE, while angiography demonstrated typical findings of AVM. Although several reports have hitherto mentioned the relationship between ALHE and AVM, the aetiology of the disease remains unknown. During the 3 years treatment course, we performed angiography several times to assess the efficacy of the treatments and compared the clinical and pathological findings, based on the hypothesis that AVM might be a cause of ALHE. This study showed first, that the clinicopathological findings of ALHE correlated with the extent of AVM shown by angiography, so that AVM could be a primary cause of ALHE. Secondly, systemic corticosteroids and local irradiation therapy produced only a temporary effect on the inflammatory changes of ALHE; therefore, surgical resection is recommended as a curative treatment. Thirdly, the patient's serum levels of renin, eosinophil cationic protein and interleukin 5 corresponded closely with the clinical course of ALHE.
AuthorsY Onishi, K Ohara
JournalThe British journal of dermatology (Br J Dermatol) Vol. 140 Issue 6 Pg. 1153-6 (Jun 1999) ISSN: 0007-0963 [Print] England
PMID10354088 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Blood Proteins
  • Eosinophil Granule Proteins
  • Interleukin-5
  • Ribonucleases
  • Renin
Topics
  • Adult
  • Angiolymphoid Hyperplasia with Eosinophilia (diagnosis, diagnostic imaging, etiology)
  • Arteriovenous Malformations (blood, complications, diagnostic imaging)
  • Blood Proteins (metabolism)
  • Ear, External
  • Eosinophil Granule Proteins
  • Eosinophils (metabolism)
  • Humans
  • Interleukin-5 (metabolism)
  • Male
  • Radiography
  • Renin (blood)
  • Ribonucleases
  • Skin (blood supply, pathology)

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