Inhibitory effects of Ougi-keishi-gomotsu-to, a traditional herbal medicine, on lipid peroxidation and protein oxidative modification of mouse brain homogenate induced by copper.

Abstract	Ougi-Keishi-gomotsu-to a traditional herbal medicine, is used clinically for patients with abnormal sensations and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification of brain homogenate induced by copper. Its effect was stronger than those of mannitol and alpha-tocopherol as free radical scavenger and antioxidant. These results demonstrated that Ougi-kelshi-gomotsu-to has antioxidative effects on neuron injury derived from oxidative stress induced by metal.
Authors	S Toda, Y Yase
Journal	Phytotherapy research : PTR (Phytother Res) Vol. 13 Issue 3 Pg. 251-3 (May 1999) ISSN: 0951-418X [Print] England
PMID	10353172 (Publication Type: Journal Article)
Chemical References	Drugs, Chinese Herbal Free Radicals Nerve Tissue Proteins ougi-keishi-gomotsu-to Copper
Topics	Animals Brain (drug effects, metabolism) Copper (pharmacology) Drugs, Chinese Herbal (pharmacology) Free Radicals Lipid Peroxidation (drug effects) Male Mice Nerve Tissue Proteins (metabolism) Oxidation-Reduction

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