Abstract | OBJECTIVE: METHODS: betahCG, immune parameters and thyroid related hormones were assayed in hyperemesis patients and in controls. RESULTS: Mean serum betahCG, fT4 and TSH levels were significantly higher in hyperemesis patients than in controls (p<0. 01, p<0.01, p<0.05, respectively). Further, immune parameters regarding IgG, IgM, C3, C4 and lymphocyte count were significantly higher in patients than in controls (p<0.05, p<0.01, p<0.01, p<0.05, p<0.01, respectively). In hyperemesis patients with hyperthyroxinemia, mean serum betahCG, IgG and IgM were significantly higher than in hyperemesis women without hyperthyroxinemia (p<0.001, p<0.05, p<0.05, respectively). BetahCG was positively correlated with fT4 (r = 0.45, p<0.05), with lymphocyte count (r = 0.47, p<0.01), with IgM (r = 0.38, p<0.05) and with C3 (r = 0.40, p<0.05) in hyperemesis patients. A negative correlation between betahCG and TSH (r = -0.43, p<0.05) was noted in the hyperemesis group. Free T4 showed a positive association to IgM (r = 0.49, p<0.01), to IgG (r = 0.40, p<0.05), to lymphocyte count (r = 0.45, p<0.05). CONCLUSION: Immunologic activity in pregnancy may have an effect or role on the stimulatory mechanism of betahCG in hyperemesis patients with or without hyperthyroxinemia.
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Authors | O A Leylek, M Toyaksi, T Erselcan, S Dokmetas |
Journal | Gynecologic and obstetric investigation
(Gynecol Obstet Invest)
Vol. 47
Issue 4
Pg. 229-34
( 1999)
ISSN: 0378-7346 [Print] Switzerland |
PMID | 10352382
(Publication Type: Journal Article)
|
Chemical References |
- Chorionic Gonadotropin, beta Subunit, Human
- Complement C3
- Complement C4
- Immunoglobulin G
- Immunoglobulin M
- Thyrotropin
- Thyroxine
|
Topics |
- Chorionic Gonadotropin, beta Subunit, Human
(blood)
- Complement C3
(analysis)
- Complement C4
(analysis)
- Female
- Humans
- Hyperemesis Gravidarum
(blood, complications, immunology)
- Hyperthyroxinemia
(complications)
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Lymphocyte Count
- Pregnancy
- Thyrotropin
(blood)
- Thyroxine
(blood)
|