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Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia.

AbstractOBJECTIVE:
This study was set up to investigate the relationship between immune process and high levels of human chorionic gonadotropin-beta (betahCG) in hyperemesis patients with or without hyperthyroxinemia.
METHODS:
betahCG, immune parameters and thyroid related hormones were assayed in hyperemesis patients and in controls.
RESULTS:
Mean serum betahCG, fT4 and TSH levels were significantly higher in hyperemesis patients than in controls (p<0. 01, p<0.01, p<0.05, respectively). Further, immune parameters regarding IgG, IgM, C3, C4 and lymphocyte count were significantly higher in patients than in controls (p<0.05, p<0.01, p<0.01, p<0.05, p<0.01, respectively). In hyperemesis patients with hyperthyroxinemia, mean serum betahCG, IgG and IgM were significantly higher than in hyperemesis women without hyperthyroxinemia (p<0.001, p<0.05, p<0.05, respectively). BetahCG was positively correlated with fT4 (r = 0.45, p<0.05), with lymphocyte count (r = 0.47, p<0.01), with IgM (r = 0.38, p<0.05) and with C3 (r = 0.40, p<0.05) in hyperemesis patients. A negative correlation between betahCG and TSH (r = -0.43, p<0.05) was noted in the hyperemesis group. Free T4 showed a positive association to IgM (r = 0.49, p<0.01), to IgG (r = 0.40, p<0.05), to lymphocyte count (r = 0.45, p<0.05).
CONCLUSION:
Immunologic activity in pregnancy may have an effect or role on the stimulatory mechanism of betahCG in hyperemesis patients with or without hyperthyroxinemia.
AuthorsO A Leylek, M Toyaksi, T Erselcan, S Dokmetas
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 47 Issue 4 Pg. 229-34 ( 1999) ISSN: 0378-7346 [Print] Switzerland
PMID10352382 (Publication Type: Journal Article)
Chemical References
  • Chorionic Gonadotropin, beta Subunit, Human
  • Complement C3
  • Complement C4
  • Immunoglobulin G
  • Immunoglobulin M
  • Thyrotropin
  • Thyroxine
Topics
  • Chorionic Gonadotropin, beta Subunit, Human (blood)
  • Complement C3 (analysis)
  • Complement C4 (analysis)
  • Female
  • Humans
  • Hyperemesis Gravidarum (blood, complications, immunology)
  • Hyperthyroxinemia (complications)
  • Immunoglobulin G (blood)
  • Immunoglobulin M (blood)
  • Lymphocyte Count
  • Pregnancy
  • Thyrotropin (blood)
  • Thyroxine (blood)

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