[A case of drug induced urolithiasis composed of acetyl sulphapyridine associated with ulcerative colitis].

Abstract

A 26-year-old female visited our hospital complaining left flank pain and macroscopic hematuria. She had been suffering ulcerative colitis and administered salazosulphapyridine and predonisolone from 17-year-old. Intravenous urography showed radiolucent multiple stones in the left renal pelvis. Three sessions of extracorporeal shock wave lithotripsy were performed after ureteral stenting. Although disintegration and discharge of the stones were satisfactory, bladder stone induced by ureteral stent was complicated. The extracted bladder stone showed a yellowish brown color and the surface was granular shape. Composition of the stone was acetyl sulphapyridine which was a metabolite of salazosulphapyridine. After maintenance of the urinary pH ranges between 6.5 and 7.5 by medication of sodium bicarbonate, the patient remains free of stone for 3 years. Drug induced urolithiasis originated from salazosulphapyridine is extremely rare. Satisfactory oral fluid intake and urinary alkalization are important for prevention of sulpha drugs calculi of urinary tract.

• Authors: R Yanagisawa, T Kamijo, Y Nagase
• Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 90 Issue 3 Pg. 462-5 (Mar 1999) ISSN: 0021-5287 [Print] Japan
• PMID: 10349305 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Gastrointestinal Agents
• N-acetylsulfapyridine
• Sulfasalazine
• Sodium Bicarbonate
• Sulfapyridine

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Colitis, Ulcerative (drug therapy)
• Female
• Gastrointestinal Agents (adverse effects)
• Humans
• Lithotripsy
• Sodium Bicarbonate (therapeutic use)
• Sulfapyridine (analogs & derivatives, analysis)
• Sulfasalazine (adverse effects)
• Urinary Calculi (chemically induced, chemistry, therapy)