Abstract | OBJECTIVE: To investigate purine metabolism in patients with systemic lupus erythematosus (SLE) for possible abnormalities that might be related to their overall impaired immune function. METHODS: RESULTS: Compared with their controls, the female SLE patients had a more than 50% reduced activity of 5'NT in the T cell fraction (p = 0.001) and in PBMC (p < 0.000). 5'NT activity was also lower in B cells, but this was not statistically significant. Enzyme activities did not correlate with indices of disease activity, disease duration or the B cell/T cell ratio and no influence of medication was found. CONCLUSION: Reduced lymphocyte 5'NT activity is a novel finding in SLE. These results indicate that purine metabolism in SLE may be disturbed. Consequences of a low 5'NT activity may be an intracellular accumulation of (deoxy) purine nucleotides and a reduction of adenosine production. It is hypothesised that these factors may play a part in the overall impaired immune function and in the chronicity of inflammation in SLE.
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Authors | J N Stolk, D G de Koning, A H Pennings, R A De Abreu, L B van de Putte, A M Boerbooms |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 58
Issue 2
Pg. 122-5
(Feb 1999)
ISSN: 0003-4967 [Print] England |
PMID | 10343529
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD19
- CD3 Complex
- Nucleotidases
- purine 5'-nucleotidase
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Topics |
- Adult
- Aged
- Antigens, CD19
- B-Lymphocytes
(enzymology, immunology)
- CD3 Complex
- Case-Control Studies
- Female
- Humans
- Leukocytes, Mononuclear
(enzymology)
- Lupus Erythematosus, Systemic
(enzymology, immunology)
- Male
- Middle Aged
- Nucleotidases
(metabolism)
- Pilot Projects
- T-Lymphocytes
(enzymology, immunology)
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