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Role of interleukin-2 receptor expression on macrophages from Salmonella-infected mice.

Abstract
In this study, it was found that macrophages from Salmonella-infected mice expressed the interleukin-2 receptor (IL-2R). The IL-2R induced by the infection consisted mainly of both beta and gamma chains, and the expression of IL-2Ralpha was very low. Furthermore, similar expression of IL-2Rbeta and gamma chains was observed in interferon-gamma-treated macrophages. The effect of recombinant interleukin-2 on the intracellular killing activity of macrophages which expressed IL-2Rbeta and gamma was then studied. Our results demonstrated that interleukin-2 acted synergistically with interferon-gamma through the IL-2R in the induction of macrophage intracellular killing activity and established a new role of IL-2R on bactericidal activity of macrophages.
AuthorsK Matsui
JournalFEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 24 Issue 1 Pg. 97-103 (May 1999) ISSN: 0928-8244 [Print] England
PMID10340718 (Publication Type: Journal Article)
Chemical References
  • Interleukin-2
  • Receptors, Interleukin-2
  • Interferon-gamma
Topics
  • Animals
  • Cells, Cultured
  • Drug Synergism
  • Flow Cytometry
  • Interferon-gamma (pharmacology)
  • Interleukin-2 (pharmacology)
  • Macrophages (drug effects, metabolism)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Interleukin-2 (analysis, physiology)
  • Salmonella Infections, Animal (immunology)
  • Salmonella typhimurium

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