Abstract |
In this study, it was found that macrophages from Salmonella-infected mice expressed the interleukin-2 receptor (IL-2R). The IL-2R induced by the infection consisted mainly of both beta and gamma chains, and the expression of IL-2Ralpha was very low. Furthermore, similar expression of IL-2Rbeta and gamma chains was observed in interferon-gamma-treated macrophages. The effect of recombinant interleukin-2 on the intracellular killing activity of macrophages which expressed IL-2Rbeta and gamma was then studied. Our results demonstrated that interleukin-2 acted synergistically with interferon-gamma through the IL-2R in the induction of macrophage intracellular killing activity and established a new role of IL-2R on bactericidal activity of macrophages.
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Authors | K Matsui |
Journal | FEMS immunology and medical microbiology
(FEMS Immunol Med Microbiol)
Vol. 24
Issue 1
Pg. 97-103
(May 1999)
ISSN: 0928-8244 [Print] England |
PMID | 10340718
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-2
- Receptors, Interleukin-2
- Interferon-gamma
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Topics |
- Animals
- Cells, Cultured
- Drug Synergism
- Flow Cytometry
- Interferon-gamma
(pharmacology)
- Interleukin-2
(pharmacology)
- Macrophages
(drug effects, metabolism)
- Male
- Mice
- Mice, Inbred BALB C
- Receptors, Interleukin-2
(analysis, physiology)
- Salmonella Infections, Animal
(immunology)
- Salmonella typhimurium
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