Abstract |
The abilities of 2-(2-methylphenyl)-5,7-dimethoxy-4-quinolyl carbonylguanidine dihydrochloride (CAS 181048-29-3, MS-31-050) and 2-phenyl-8-(2-methoxyethoxy)-4-quinolyl carbonylguanidine bismethanesulfonate (CAS 181048-36-2, MS-31-038) in inhibiting Na(+)-H+ exchange, ischemia- and reperfusion-induced injury were determined and compared with those of 4-isopropyl-3-methylsulfonylbenzoyl guanidine methanesulfonate (CAS 159138-81-5, IMGM), a selective inhibitor of Na(+)-H+ exchange. MS-31-050 and IMGM exhibited comparable inhibitory effects on Na(+)-dependent pH recovery and antiarrhythmic effects during ischemia in anesthetized rats. In rats subjected to ischemia and reperfusion, MS-31-050 (10 mg/kg i.v.) significantly reduced the infarct size when given prior to the onset of ischemia. However, postischemic treatment with either MS-31-050 or IMGM failed to protect reperfused hearts. In contrast, MS-31-038 reduced the infarct size dramatically from 65.4 +/- 7.4% in control to 29.9 +/- 11.6% at 3 mg/kg and 9.8 +/- 3.4% at 10 mg/kg even when administered before the onset of reperfusion. These results suggest the beneficial effects of Na(+)-H+ exchange inhibitors on myocardial ischemia/ reperfusion injury.
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Authors | H Banno, J Fujiwara, J Hosoya, T Kitamori, H Mori, H Yamashita, F Ikeda |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 49
Issue 4
Pg. 304-10
(Apr 1999)
ISSN: 0004-4172 [Print] Germany |
PMID | 10337448
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Quinolines
- Sodium-Hydrogen Exchangers
- MS 31-038
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Topics |
- Anesthesia
- Animals
- Enzyme Inhibitors
(therapeutic use)
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Male
- Mesenteric Arteries
(drug effects, metabolism)
- Muscle, Smooth, Vascular
(drug effects, metabolism)
- Myocardial Infarction
(drug therapy, pathology)
- Myocardial Ischemia
(complications)
- Myocardial Reperfusion Injury
(pathology, prevention & control)
- Quinolines
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Sodium-Hydrogen Exchangers
(antagonists & inhibitors)
- Tachycardia
(etiology, prevention & control)
- Ventricular Fibrillation
(etiology, prevention & control)
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