Carbamazepine-induced hepatorenal failure in a child.

Abstract

Carbamazepine is used to manage generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders in children. It is frequently associated with neurologic adverse events, Stevens-Johnson syndrome, and hematologic side effects. Hepatic and renal adverse effects are less common but can cause death. A 6-year-old boy receiving carbamazepine for partial seizure disorder developed hepatorenal failure. With discontinuation of the drug, his liver and kidney function returned to normal within 2 weeks.

• Authors: M R Haase
• Journal: Pharmacotherapy (Pharmacotherapy) Vol. 19 Issue 5 Pg. 667-71 (May 1999) ISSN: 0277-0008 [Print] United States
• PMID: 10331832 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Carbamazepine

Topics

• Anticonvulsants (adverse effects)
• Carbamazepine (adverse effects)
• Child
• Humans
• Liver Failure (chemically induced)
• Male
• Renal Insufficiency (chemically induced)