Abstract |
We report a fetus from an elective termination at 17 weeks gestation following maternal ingestion of 1200 micrograms of misoprostol at 7 weeks of gestation. The fetus had abscence of the middle and distal phalanges of fingers 1, 3, 4 and 5 with tethering by thin strands of tissue on one hand, a below-knee amputation of one leg and omphalocele. There was absence of amnion on the chorionic surface of the placenta, a pathologic feature of early amnion rupture. The association in this case of the phenotypic features of the amniotic band syndrome suggests that the teratogenicity of misoprostol at 9 to 12 weeks gestation can overlap that of other acute insults at that time, such as chorionic villus sampling, dilatation and curettage and abdominal trauma in the first trimester.
|
Authors | D R Genest, D Di Salvo, M J Rosenblatt, L B Holmes |
Journal | Clinical dysmorphology
(Clin Dysmorphol)
Vol. 8
Issue 1
Pg. 53-8
(Jan 1999)
ISSN: 0962-8827 [Print] England |
PMID | 10327252
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
- Abortifacient Agents, Nonsteroidal
- Misoprostol
|
Topics |
- Abnormalities, Drug-Induced
- Abortifacient Agents, Nonsteroidal
(adverse effects)
- Adult
- Female
- Hernia, Umbilical
(chemically induced)
- Humans
- Limb Deformities, Congenital
(chemically induced)
- Misoprostol
(adverse effects)
- Pregnancy
- Pregnancy Trimester, First
- Ultrasonography, Prenatal
|