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Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats.

Abstract
Nocistatin is a biologically active peptide derived from prepronociceptin, and its intrathecal administration has been reported to reduce nociceptin- or prostaglandin E2-induced hyperalgesia and allodynia in mice. In this study, we investigated the effects of intracerebroventricular (i.c.v.) administration of nocistatin on the inflammatory hyperalgesia induced by hindlimb intraplantar injection of carrageenan/kaolin in the rat paw-pressure test. Intracerebroventricular administration of nocistatin (0.5-50 pmol/rat) dose-dependently reduced carrageenan/kaolin-induced hyperalgesia, which peaked at 15-30 m. However, i.c.v. administration of nocistatin (50 pmol/rat) had no effect on the nociceptive threshold of non-inflamed rats. These results indicate that nocistatin has anti-hyperalgesic effects on the inflammatory hyperalgesia induced by carrageenan/kaolin at the supraspinal level.
AuthorsT Nakagawa, M Kaneko, S Inamura, M Satoh
JournalNeuroscience letters (Neurosci Lett) Vol. 265 Issue 1 Pg. 64-6 (Apr 09 1999) ISSN: 0304-3940 [Print] Ireland
PMID10327207 (Publication Type: Journal Article)
Chemical References
  • Opioid Peptides
  • nocistatin
  • Kaolin
  • Carrageenan
Topics
  • Animals
  • Carrageenan
  • Drug Evaluation, Preclinical
  • Hindlimb
  • Hyperalgesia (drug therapy, etiology)
  • Inflammation (chemically induced)
  • Injections, Intraventricular
  • Kaolin
  • Male
  • Opioid Peptides (therapeutic use)
  • Rats
  • Rats, Sprague-Dawley

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