HLA-C locus alleles in patients with psoriatic arthritis (PsA).

Abstract

The aim of this investigation was to compare the frequency of alleles at the HLA-C locus in patients with psoriatic arthritis to that in the disease free population and to relate the HLA genes to disease phenotype in psoriatic arthritis (PsA). Ninety-four consecutive patients seen in the (PsA) clinic between April and July 1996 and 100 disease-free controls had HLA typing performed by both serologic and molecular techniques. Patients' disease was assessed according to a standard protocol. Fisher's exact test was used to compare the frequency of HLA alleles in the patients and controls. HLA-C determined by PCR-SSP decreased the frequency of non-identified, that is, "blank" (or null) alleles to 6% in patients and controls. HLA-Cw*0602 was present in 32 patients and 18 controls: allele frequency of 17% in the patients versus 9% in the controls (p < 0.01). Amongst patients with psoriatic arthritis, those who carried the HLA-Cw*0602 allele had a significantly earlier mean age of onset of their psoriasis (p = 0.003). This study confirms that molecular DNA techniques improve detection of C-locus alleles. The HLA-Cw*0602 is increased amongst patients with psoriatic arthritis compared to controls. The HLA-Cw*0602 is associated with an earlier age of onset of psoriasis.

• Authors: D D Gladman, C Cheung, C M Ng, J A Wade
• Journal: Human immunology (Hum Immunol) Vol. 60 Issue 3 Pg. 259-61 (Mar 1999) ISSN: 0198-8859 [Print] United States
• PMID: 10321964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-C Antigens

Topics

• Age of Onset
• Alleles
• Arthritis, Psoriatic (genetics, immunology)
• Female
• Gene Frequency
• HLA-C Antigens (genetics)
• Humans
• Male
• Middle Aged
• White People