Abstract |
Reduced somatomedin activity was uniformly present pre-dialysis in 7 children with end-stage renal disease. Somatomedin activity improved in 6 of the 7 patients following a single 5 hr hemodialysis. Percent normal growth correlated with post-dialysis somatomedin activity in 6 of the 7 children. No correlation was present between percent normal growth and calorie or protein intake. Reduced somatomedin activity in children with end-stage renal disease appears to be due to a circulating uremic inhibitor(s). Somatomedin activity may be a useful in vitro test for adequacy of dialysis in children. Further efforts are necessary to identify the inhibitor(s) of somatomedin activity in uremia.
|
Authors | A J Pennisi, L S Phillips, C Uittenbogaart, R B Ettenger, M H Malekzadeh, R N Fine |
Journal | Proceedings of the Clinical Dialysis and Transplant Forum
(Proc Clin Dial Transplant Forum)
1976 Nov 19-22
Vol. 6
Pg. 181-3
ISSN: 0094-6044 [Print] United States |
PMID | 1029883
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Body Height
- Child
- Child Nutritional Physiological Phenomena
- Child, Preschool
- Female
- Growth
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Renal Dialysis
- Somatomedins
(blood)
|