[Autoradiographic study of the rate of collagen synthesis under conditions of stimulation of the wound process].

Abstract

A study was made of the rate of the tropocollagen synthesis by the granulation tissue fibroblasts and of its passage into the intercellular space in control animals and under conditions of stimulation of the wound process by potassium orotate, one of the pyrimidine series derivatives. It appeared that the process of tropocollagen synthesis became accelerated under the effect of the stimulant; collagen fiber precursor appeared in the intercellular space earlier than in control and became included into the fibrous structures of the granulation tissue, this correlating with the intensification of the RNA synthesis in the fibroblast nuclei and an accelerated passage of the newly-synthesized RNA from the nucleus into the cell cytoplasm under analogous conditions. There was noted no sharp excess of collagen in the granulation tissue of animals given potassium orotate.

• Authors: G N Dudnikova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 82 Issue 10 Pg. 1256-8 (Oct 1976) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Avtoradiograficheskoe issledovanie skorosti sinteza kollagena v usloviiakh stimuliatsii ranevogo protsessa.
• PMID: 1029516 (Publication Type: English Abstract, Journal Article)

Chemical References

• Tropocollagen
• Tritium
• Orotic Acid
• RNA
• Proline
• Potassium

Topics

• Animals
• Autoradiography
• Fibroblasts (metabolism)
• Granulation Tissue (pathology)
• Isotope Labeling
• Mice
• Orotic Acid (pharmacology)
• Potassium (pharmacology)
• Proline
• RNA (metabolism)
• Stimulation, Chemical
• Tritium
• Tropocollagen (biosynthesis)
• Wound Healing