[Fructose-1,6-diphosphate aldolase and ketose-1-phosphate aldolase isoenzyme spectra in the kidneys normally and in uranyl acetate poisoning].

Abstract

Activities of both aldolases were distinctly decreased in acute kidney insufficiency, caused by administration of uranyl acetate. The decrease in the activity of fructose-1,6-diphosptate aldolase was more distinct which led to alteration in ratio between fructose -1,6-diphosphate and ketose-1-phosphate aldolases. The isozyme spectra of the enzymes were also altered. Isozymes of fructose-1,6-diphosphate aldolase AB2 and of ketose-1-phosphate aldolase form 22 possessed the same electrophoretic mobility but their relative activity was increased 2-3-fold under conditions of the acute kidney insufficiency. At the same time, the more electrophoretically mobile isozymes were not detected.

• Authors: L A Khomenko, N M Petrun'
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1976 Jul-Aug Vol. 22 Issue 4 Pg. 478-81 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izofermentnye spektry fruktozo-1,6-difosfatal'dolazy i ketozo-1-fosfatal'dolazy v pochkakh v norme i pri otravlenii uranilatsetatom
• PMID: 1027233 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acetates
• Isoenzymes
• Uranium
• Aldehyde-Lyases
• Fructose-Bisphosphate Aldolase

Topics

• Acetates (poisoning)
• Acute Disease
• Aldehyde-Lyases (metabolism)
• Animals
• Enzyme Activation (drug effects)
• Fructose-Bisphosphate Aldolase (metabolism)
• Isoenzymes (metabolism)
• Kidney (enzymology)
• Kidney Tubules (enzymology)
• Male
• Poisoning (enzymology)
• Rats
• Time Factors
• Uranium (poisoning)