[Experimental combined administration of cyclophosphane with serotonin, insulin and glucose].

Abstract

Experiments on mice with sarcoma 37 evidenced that the use of cyclophosphan in combination with serotonin, insulin, insulin + glucose and serotonin + glucose enable it to obtain a more significant antineoplasic effect than this is possible by the treatment with cyclophan alone. A combined application of these agents produced a more profound inhibition of the glycogen-forming function and restitution of the glycogen cintent in the liver of the test animals occurred quicker than when cyclophosphan alone was used. In oncological practice it is recommended to use combinations of cyclophosphan with serotonin, insulin, insulin + glucose and serotonin + glucose.

• Authors: N A Vvedenskaia, Zh F Presnova
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1976 Nov-Dec Vol. 39 Issue 6 Pg. 709-12 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Kombinirovannoe primenenie tsiklofosfana s serotoninom, insulinom i gliukozoĭ v éksperimente
• PMID: 1024839 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Insulin
• Liver Glycogen
• Serotonin
• Cyclophosphamide
• Glucose

Topics

• Animals
• Antineoplastic Agents
• Cyclophosphamide (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Glucose (administration & dosage, therapeutic use)
• Insulin (administration & dosage, therapeutic use)
• Liver Glycogen (biosynthesis)
• Male
• Mice
• Neoplasm Transplantation
• Sarcoma 37 (drug therapy, metabolism)
• Serotonin (administration & dosage, therapeutic use)
• Time Factors
• Transplantation, Homologous