Evaluation of semicarbazones for anticonvulsant and sedative-hypnotic properties.

Abstract

A series of semicarbazones and thiosemicarbazones were synthesized and evaluated for anti-convulsant activity. Some compounds provided significant protection against Maximal Electroshock (MES) and subcutaneous strychnine induced seizures. Compound 1 was the most active in the series with activity in a dose of 30 mg/kg in the strychnine seizure pattern test and an ED50 of 10 mg/kg in the MES test. Hence it could serve as a prototype molecule for future development. Also compounds with a p-nitrophenyl substitution in place of the amino hydrogen of semicarbazone moiety showed activity in a dose of 30 mg/kg and an ED50 of 83 mg/kg in the MES test.

• Authors: S N Pandeya, N Aggarwal, J S Jain
• Journal: Die Pharmazie (Pharmazie) Vol. 54 Issue 4 Pg. 300-2 (Apr 1999) ISSN: 0031-7144 [Print] Germany
• PMID: 10234743 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Convulsants
• Hypnotics and Sedatives
• Semicarbazones
• Strychnine

Topics

• Animals
• Anticonvulsants (chemical synthesis, chemistry, pharmacology)
• Convulsants (toxicity)
• Electroshock
• Hypnotics and Sedatives (chemical synthesis, chemistry, pharmacology)
• Magnetic Resonance Spectroscopy
• Mice
• Postural Balance (drug effects)
• Seizures (chemically induced, prevention & control)
• Semicarbazones (chemical synthesis, chemistry, pharmacology)
• Sleep (drug effects)
• Spectrophotometry, Infrared
• Structure-Activity Relationship
• Strychnine (antagonists & inhibitors, toxicity)
• Time Factors