[A giant invasive thymoma made resectable by cisplatin + vincristine + doxorubicin + etoposide (CODE)].

A 39-year-old man experienced cough and dyspnea by right massive pleural effusion. A large tumor was found in the anterior mediastinum and it had invaded the chest wall all around. The diagnosis was invasive thymoma stage IV a by biopsy. His tumor was too large to be resected, so chemotherapy was planned. The tumor responded well to cisplatin + etoposide until day 7, but it relapsed immediately between doses. Hence, we administered cisplatin + vincristine + doxorubicin + etoposide (CODE) with G-CSF for its high-dose intensity. The tumor diminished in size, and the chest wall invasion almost disappeared. An operation was performed. We describe our experience with a case of invasive thymoma which responded to CODE.
AuthorsT Hosokawa, H Maki, T Saito, M Harada, H Isobe
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 26 Issue 5 Pg. 697-701 (Apr 1999) ISSN: 0385-0684 [Print] JAPAN
PMID10234303 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cisplatin
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Cisplatin (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Drug Administration Schedule
  • Etoposide (administration & dosage)
  • Humans
  • Male
  • Neoplasm Invasiveness
  • Pleural Effusion, Malignant (drug therapy, etiology)
  • Thymoma (drug therapy, pathology)
  • Thymus Neoplasms (drug therapy, pathology)
  • Vincristine (administration & dosage)

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