Abstract |
According to estrogen receptor (ER) and menopausal status, operable breast cancer patients were randomized for adjuvant endocrine therapy with tamoxifen (TAM) in premenopausal patients, after oophorectomy ( OVEX), chemotherapy, CHEM ( mitomycin C+ oral cyclophosphamide), or chemo-endocrine therapy (TAM + CHEM). Some 1579 patients were entered in the trial between 9, 1978 and 12, 1991, with a median follow-up of 10 years. In ER-positive, premenopausal patients there were no significant differences in relapse-free (RFS) or overall survival (OS) among the OVEX + TAM, CHEM, and CHEM + TAM arms. On the contrary, in ER-positive, post-menopausal patients, the chemoendocrine therapy showed a significantly better OS (p = 0.0254) with a trend of better RFS (p = 0.0674), as compared with TAM or CHEM groups. ER-negative, premenopausal patients showed no significant differences in RFS or OS between CHEM and CHEM + TAM arms. In ER-negative, postmenopausal patients, there was a non-significantly better RFS (p = 0.0888) and a significantly better OS (p = 0.0332) in CHEM + TAM group than in the CHEM alone group. These results suggest that ER and menopausal status are important criteria to select early breast cancer patients for adjuvant treatments.
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Authors | Y Nomura, S Tsutsui, S Murakami, Y Takenaka |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 26
Issue 5
Pg. 643-9
(Apr 1999)
ISSN: 0385-0684 [Print] Japan |
PMID | 10234295
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Receptors, Estrogen
- Tamoxifen
- Mitomycin
- Cyclophosphamide
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Topics |
- Adult
- Aged
- Antineoplastic Agents, Hormonal
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(chemistry, drug therapy, mortality, surgery)
- Chemotherapy, Adjuvant
- Cyclophosphamide
(administration & dosage)
- Female
- Humans
- Mastectomy
- Menopause
- Middle Aged
- Mitomycin
(administration & dosage)
- Receptors, Estrogen
(analysis)
- Survival Rate
- Tamoxifen
(administration & dosage)
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