[Clinical study of dantrolene sodium in the treatment of spastic and dystonic syndromes].

Abstract

Dantrolene sodium has been given to 45 patients suffering from dyskinetic syndromes: 33 were suffering from spastic syndromes, either secondary to cerebral lesions at birth, or to other cerebral lesions, or to cord lesions; 9 were affected by infantile dystonic syndromes; 1 by dystonia muscolorum deformans and the last 2 patients were suffering from parkinsonism. The best dosage schedule was individual and ranged from 50 mg to 300 mg a day. In this range, the majority of the spastic patients showed reduction of spasticity, unrelated with the site of pathology: a slight one in 12 patients, a moderate one in 9 and a marked one in 2. On the contrary, slight improvement has been noticed in only two of the patients suffering from dystonic syndromes. In no case side effects has been noticed. In all patients who underwent slight or moderate improvement only, we tried to obtain better results on spasticity by growing the dosage schedules; but we have always noticed side effects, that is weakness or drowsiness and, sometimes, urinary uncontinence. Moreover 2 patients showed evidence of transitory metabolic side effects. Therefore our experience shows that dantrolene sodium is an useful drug into the therapy of spasticity, even if often a slight of moderate improvement only is achieved. Slow increase in dosage schedule, repeated laboratory controls and alternate periods of treatment and suspended treatment should be observed.

• Authors: B Fraioli, G Guglielmi, L Baldassarre
• Journal: Rivista di neurologia (Riv Neurol) 1976 Jul-Aug Vol. 46 Issue 4 Pg. 333-50 ISSN: 0035-6344 [Print] Italy
• Vernacular Title: Studio clinico del dantrolene sodium nel trattamento delle sindromi spastiche e distoniche
• PMID: 1023344 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydantoins
• Dantrolene

Topics

• Adolescent
• Adult
• Aged
• Cerebrovascular Disorders (drug therapy)
• Child
• Child, Preschool
• Dantrolene (therapeutic use)
• Female
• Hemiplegia (drug therapy)
• Humans
• Hydantoins (therapeutic use)
• Male
• Middle Aged
• Movement Disorders (drug therapy)
• Multiple Sclerosis (drug therapy)
• Nervous System Diseases (drug therapy)
• Parkinson Disease (drug therapy)