Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells.

Abstract

Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.

• Authors: K Saeki, Y Shoji, T Noro, T Miyase, Y Nakamura, M Funayama, M Isemura
• Journal: Planta medica (Planta Med) Vol. 65 Issue 3 Pg. 227-9 (Apr 1999) ISSN: 0032-0943 [Print] Germany
• PMID: 10232066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Hexoses
• Gallic Acid
• 1,2,3,6-tetragalloylglucose
• Glucose
• hamamelitannin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Carcinoma, Lewis Lung (pathology)
• Cell Division (drug effects)
• Gallic Acid (analogs & derivatives, pharmacology)
• Glucose (analogs & derivatives, pharmacology)
• Hexoses (pharmacology)
• Mice
• Neoplasm Invasiveness
• Tumor Cells, Cultured