Abstract |
The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were assessed. Mean signal intensity vs. time curves were plotted. Well-shaped curves of the first pass of the contrast agent were only obtained with Gd-DOTA. According to these results it appears difficult to assess tumor blood volume with USPIO dynamic susceptibility contrast imaging.
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Authors | P Loubeyre, T De Jaegere, Y Miao, W Landuyt, G Marchal |
Journal | Magnetic resonance imaging
(Magn Reson Imaging)
Vol. 17
Issue 4
Pg. 627-31
(May 1999)
ISSN: 0730-725X [Print] Netherlands |
PMID | 10231190
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Dextrans
- Heterocyclic Compounds
- Magnetite Nanoparticles
- Organometallic Compounds
- Oxides
- ferumoxtran-10
- gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
- Gadolinium
- Iron
- Ferrosoferric Oxide
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Topics |
- Animals
- Contrast Media
- Dextrans
- Echo-Planar Imaging
(methods)
- Feasibility Studies
- Ferrosoferric Oxide
- Gadolinium
- Heterocyclic Compounds
- Hindlimb
- Iron
- Magnetic Resonance Imaging
(methods)
- Magnetite Nanoparticles
- Male
- Neoplasm Transplantation
- Organometallic Compounds
- Oxides
- Rats
- Rats, Wistar
- Rhabdomyosarcoma
(pathology)
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