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Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats.

Abstract
The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were assessed. Mean signal intensity vs. time curves were plotted. Well-shaped curves of the first pass of the contrast agent were only obtained with Gd-DOTA. According to these results it appears difficult to assess tumor blood volume with USPIO dynamic susceptibility contrast imaging.
AuthorsP Loubeyre, T De Jaegere, Y Miao, W Landuyt, G Marchal
JournalMagnetic resonance imaging (Magn Reson Imaging) Vol. 17 Issue 4 Pg. 627-31 (May 1999) ISSN: 0730-725X [Print] Netherlands
PMID10231190 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Dextrans
  • Heterocyclic Compounds
  • Magnetite Nanoparticles
  • Organometallic Compounds
  • Oxides
  • ferumoxtran-10
  • gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
  • Gadolinium
  • Iron
  • Ferrosoferric Oxide
Topics
  • Animals
  • Contrast Media
  • Dextrans
  • Echo-Planar Imaging (methods)
  • Feasibility Studies
  • Ferrosoferric Oxide
  • Gadolinium
  • Heterocyclic Compounds
  • Hindlimb
  • Iron
  • Magnetic Resonance Imaging (methods)
  • Magnetite Nanoparticles
  • Male
  • Neoplasm Transplantation
  • Organometallic Compounds
  • Oxides
  • Rats
  • Rats, Wistar
  • Rhabdomyosarcoma (pathology)

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