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Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer.

Abstract
Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, developed quadriplegia. Electroneurophysiological examination, as well as a muscle biopsy, showed a typical picture of acute quadriplegic myopathy with loss of thick filament proteins. This is, to the best of our knowledge, the first reported case of this complication following APSCT.
AuthorsJ Samuelsson, H Zackrisson, L Tokics, P Ljungman, E Lidbrink, P Pircher, L Larsson
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 23 Issue 8 Pg. 835-7 (Apr 1999) ISSN: 0268-3369 [Print] England
PMID10231149 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Acute Disease
  • Breast Neoplasms (therapy)
  • Female
  • Hematopoietic Stem Cell Transplantation (adverse effects)
  • Humans
  • Middle Aged
  • Quadriplegia (etiology)
  • Transplantation, Autologous

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