Abstract |
We studied the immunoprotective effect of IM-133, a poly-herbal formulation, against E. coli-induced intra-abdominal sepsis. Treatment with IM-133 afforded protection against the septic shock induced mortality. The in vivo treatment has enhanced nitric oxide production and phagocytic ability against C. albicans by peritoneal macrophages in Balb/c mice. The protective effect of IM-133 appears to be by virtue of its immunomodulatory activity and finds application in the clearance of intra-cellular pathogens.
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Authors | S K Mitra, M Gupta, T Suryanarayana, D N Sarma |
Journal | International journal of immunopharmacology
(Int J Immunopharmacol)
Vol. 21
Issue 2
Pg. 115-20
(Feb 1999)
ISSN: 0192-0561 [Print] England |
PMID | 10230874
(Publication Type: Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Nitric Oxide
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Topics |
- Adjuvants, Immunologic
(pharmacology)
- Animals
- Female
- Male
- Medicine, Ayurvedic
- Mice
- Mice, Inbred BALB C
- Nitric Oxide
(biosynthesis)
- Phagocytosis
(drug effects)
- Phytotherapy
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