| Abstract | PURPOSE: Needle biopsy of the liver is a common diagnostic procedure. Although relatively safe, bleeding remains a potential complication and may occur more frequently in patients with coagulopathy. The purpose of this study was to evaluate the utility of a fibrin sealant in preventing bleeding after a 15-gauge needle biopsy of the liver in a canine model heparinized to simulate coagulopathy. MATERIALS AND METHODS: Fibrin sealant was delivered to biopsy tract sites in eight dogs anticoagulated with heparin (activated clotting time 387 seconds +/- 94) using the same sheath system that was employed to obtain the biopsy specimen. RESULTS: The results demonstrated complete hemostasis in the sealant-plugged tracts as compared to controls. Continuous bleeding was observed in none of the fibrin sealant-treated sites, compared with all of the control biopsy sites (P = .0078). CONCLUSION: These results demonstrate the high degree of efficacy of fibrin sealant delivered through a sheath system in plugging liver biopsy tracts and eliminating bleeding in a severely coagulopathic animal model. This indicates that fibrin sealant use in cutting needle biopsies can reduce major and minor complications associated with the procedure. |
| Authors | J K Falstrom, M M Moore, S H Caldwell, A H Matsumoto, R D Abbott, W D Spotnitz
(Affiliation: Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22906-0005, USA.)
|
| Journal | Journal of vascular and interventional radiology : JVIR
(J Vasc Interv Radiol)
Vol. 10
Issue 4
Pg. 457-62
(Apr 1999)
ISSN: 1051-0443 UNITED STATES |
| PMID | 10229475
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anticoagulants
- Fibrin Tissue Adhesive
- Hemostatics
- Tissue Adhesives
- Heparin
|
| Topics |
- Animals
- Anticoagulants
(administration & dosage, adverse effects)
- Biopsy, Needle
(adverse effects, instrumentation, methods)
- Disease Models, Animal
- Dogs
- Drug Delivery Systems
- Fibrin Tissue Adhesive
(administration & dosage, chemical synthesis, therapeutic use)
- Hemorrhage
(prevention & control)
- Hemostatics
(administration & dosage, chemical synthesis, therapeutic use)
- Heparin
(administration & dosage, adverse effects)
- Liver
(pathology)
- Liver Diseases
(prevention & control)
- Needles
- Syringes
- Tissue Adhesives
(chemical synthesis, therapeutic use)
|
