[Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid].

Abstract

We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996. Sensitivity and specificity of these two tests were high. This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.

• Authors: J P Brandel, P Beaudry, N Delasnerie-Lauprêtre, J L Laplanche
• Journal: Revue neurologique (Rev Neurol (Paris)) Vol. 155 Issue 2 Pg. 148-51 (Feb 1999) ISSN: 0035-3787 [Print] France
• Vernacular Title: Maladie de Creutzfeldt-Jakob: valeur diagnostique de la détection de la protéine 14-3-3 et du dosage de la NSE dans le liquide céphalo-rachidien.
• PMID: 10226319 (Publication Type: English Abstract, Journal Article)

Chemical References

• 14-3-3 Proteins
• Cerebrospinal Fluid Proteins
• Proteins
• Tyrosine 3-Monooxygenase
• Phosphopyruvate Hydratase

Topics

• 14-3-3 Proteins
• Cerebrospinal Fluid Proteins (analysis)
• Creutzfeldt-Jakob Syndrome (cerebrospinal fluid, diagnosis, enzymology)
• Electroencephalography
• Epilepsies, Myoclonic (diagnosis)
• Humans
• Phosphopyruvate Hydratase (metabolism)
• Predictive Value of Tests
• Proteins (analysis)
• Retrospective Studies
• Tyrosine 3-Monooxygenase