Medicinal applications of heavy-metal compounds.

Abstract

A brief summary of the key role for certain heavy-metal compounds in medicine is discussed, with a special focus on very recent findings in the following four topics: platinum anti-tumor compounds (novel mononuclear compounds, dinuclear compounds and trinuclear compounds with promising activity); ruthenium anti-tumor compounds (the first clinical trial for a Ru compound has begun); gadolinium NMR-imaging compounds (association with biomacromolecules is now possible); technetium compounds (the use of organometallic precursors opens a plethora of new species and enables the labeling of, for example, neurotransmitter molecules).

• Authors: J Reedijk
• Journal: Current opinion in chemical biology (Curr Opin Chem Biol) Vol. 3 Issue 2 Pg. 236-40 (Apr 1999) ISSN: 1367-5931 [Print] England
• PMID: 10226048 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Metals, Heavy
• Radiopharmaceuticals

Topics

• Antineoplastic Agents (chemistry, therapeutic use)
• Metals, Heavy (chemistry, therapeutic use)
• Radiopharmaceuticals