Abstract |
The efficacy of plasmapheresis for the treatment of toxic epidermal necrolysis (TEN) in our patient and related reports in the literature were examined. The patient, a 41-year-old female, was diagnosed as having drug (Sedes-G [isopropylantipyrin, arylisopropylacetoureid, and phenacetinum]) induced TEN. Upon admission to our hospital, extensive corticostroid therapy was initiated. After 6 days, because more than 90% of the patient's body surface was affected by TEN, it was concluded that the patient was unresponsive to corticosteroid therapy. Double filtration plasmapheresis (DFPP) was therefore begun. After 2 sessions of DFPP, extensive reepithelialization rapidly occurred, and after 3 sessions of DFPP, the improvement was dramatic. The patient's condition had almost healed during 1 month's hospitalization. It has been reported in the literature that 22 patients with drug induced TEN have been treated with plasmapheresis. The mortality rate of 23 patients, including our patient, was 17.4%. The rate of effectiveness of plasmapheresis on drug induced TEN is 82.6%. It appears that some kind of necrolytic factors were removed by the plasmapheresis. This suggests that plasmapheresis may be an effective treatment for drug induced TEN.
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Authors | H Yamada, K Takamori, H Yaguchi, H Ogawa |
Journal | Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
(Ther Apher)
Vol. 2
Issue 2
Pg. 153-6
(May 1998)
ISSN: 1091-6660 [Print] United States |
PMID | 10225718
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Adult
- Drug Combinations
- Female
- Humans
- Plasmapheresis
(methods)
- Stevens-Johnson Syndrome
(etiology, therapy)
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