Radiation therapy, cisplatin and hyperthermia in combination in management of patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes.

Abstract

Fifty-three patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes were treated with radiation therapy (median, 70 Gy), cisplatin (median, 6 weekly courses) and hyperthermia (median, 6 twice weekly sessions). Local complete response was achieved in 82% and nodal complete response in 85% of patients. Overall survival was 51% and disease-free survival was 54% at 2 years. Toxicity was acceptable. Radiation therapy, cisplatin and hyperthermia in combination prove to be effective and safe in management of these patients.

• Authors: M Serin, H S Erkal, A Cakmak
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 50 Issue 1 Pg. 103-6 (Jan 1999) ISSN: 0167-8140 [Print] Ireland
• PMID: 10225563 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Cobalt Radioisotopes
• Radiopharmaceuticals
• Cisplatin

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Agents (adverse effects, therapeutic use)
• Carcinoma (drug therapy, radiotherapy, secondary, therapy)
• Cisplatin (adverse effects, therapeutic use)
• Cobalt Radioisotopes (adverse effects, therapeutic use)
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Follow-Up Studies
• Head and Neck Neoplasms (drug therapy, radiotherapy, therapy)
• Humans
• Hyperthermia, Induced (adverse effects)
• Lymphatic Metastasis (pathology, radiotherapy)
• Male
• Middle Aged
• Neck
• Prospective Studies
• Radiopharmaceuticals (adverse effects, therapeutic use)
• Radiotherapy Dosage
• Remission Induction
• Survival Rate