Abstract |
T-3762 is an injectable new quinolone with a broad spectrum of antibacterial activity. Pazufloxacin (T-3761) is an active form of T-3762. The minimal inhibitory concentrations (MICs) of pazufloxacin for 50% of the clinical isolates tested were 3.13 microg/ml for Streptococcus agalactiae, 6.25 microg/ml for Gardnerella vaginalis, 0.025 microg/ml for Escherichia coli, 0.78 microg/ml for Pseudomonas aeruginosa, 6.25 microg/ml for Peptostreptococcus magnus, 6.25 microg/ml for Bacteroides fragilis and 12.5 microg/ml for Prevotella bivia. The MICs of T-3762 for 90% of the clinical isolates tested were 3.13 microg/ml for S. agalactiae, 6.25 microg/ml for G. vaginalis, 0.10 microg/ml for E. coli, 12.5 microg/ml for P. aeruginosa, 25 microg/ml for P. magnus, 12.5 microg/ml for B. fragilis and 25 microg/ml for P. bivia. The results of this study suggest that, subject to confirmation by clinical trials, T-3762, in combination with an agent with reliable activity against anaerobic bacteria, is suitable as an empirical therapy of patients with obstetric and gynecological infections.
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Authors | H Mikamo, Y Sato, Y Hayasaki, K Kawazoe, T Tamaya |
Journal | Chemotherapy
(Chemotherapy)
1999 May-Jun
Vol. 45
Issue 3
Pg. 154-7
ISSN: 0009-3157 [Print] Switzerland |
PMID | 10224336
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Antitubercular Agents
- Fluoroquinolones
- Oxazines
- pazufloxacin
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Topics |
- Anti-Infective Agents
(pharmacology)
- Antitubercular Agents
(pharmacology)
- Bacteria, Anaerobic
(drug effects)
- Bacteroides fragilis
(drug effects)
- Escherichia coli
(drug effects)
- Female
- Fluoroquinolones
- Gardnerella vaginalis
(drug effects)
- Humans
- Microbial Sensitivity Tests
- Oxazines
(pharmacology)
- Peptostreptococcus
(drug effects)
- Prevotella
(drug effects)
- Pseudomonas aeruginosa
(drug effects)
- Streptococcus agalactiae
(drug effects)
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