Abstract |
A total of 329 novel adamantane derivatives have been synthesized and pharmacologically studied. Among them, the compounds containing halogen-containing aromatic radicals in the second position show the most pronounced effect on animal resistance to the emergencies induced by its habitat and performance. N-(2-adamantyl)-N-(para-bromphenyl)amine ( bromantane) possesses a low toxicity, a high ability to enhance the physical and operant working maintenance of animals, to accelerate its recovery in developed fatigue, in hyperthermia and hypoxia in particular. 2-(para-chlorobenzoylamine)adamantane (chlodantane) has the processes of a rapid-action adaptogenic agent by enhancing the resistance of animals to various physical and toxically chemical noxious agents. The two compounds have immunostimulating effects in secondary stress-induced immunodeficiencies whose mechanism of action is a membranous protective activity.
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Authors | I S Morozov, N V Klimova, S A Sergeeva, I A Ivanova, V G Barchukov, G I Kovalev, B M Piatin, N I Avdiunina |
Journal | Vestnik Rossiiskoi akademii meditsinskikh nauk
(Vestn Ross Akad Med Nauk)
Issue 3
Pg. 28-32
( 1999)
ISSN: 0869-6047 [Print] Russia (Federation) |
Vernacular Title | Proizvodnye adamantana, povyshaiushchie ustoĭchivost' organizma k ékstremal'nym vozdeĭstviiam. |
PMID | 10222828
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Psychotropic Drugs
- Amantadine
- bromantane
- Adamantane
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Topics |
- Adamantane
(analogs & derivatives)
- Amantadine
(analogs & derivatives, pharmacology)
- Animals
- General Adaptation Syndrome
(prevention & control)
- Humans
- Mice
- Psychotropic Drugs
(pharmacology)
- Rats
- Stress, Psychological
(drug therapy)
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