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[Adamantane derivatives enhancing body's resistance to emergencies].

Abstract
A total of 329 novel adamantane derivatives have been synthesized and pharmacologically studied. Among them, the compounds containing halogen-containing aromatic radicals in the second position show the most pronounced effect on animal resistance to the emergencies induced by its habitat and performance. N-(2-adamantyl)-N-(para-bromphenyl)amine (bromantane) possesses a low toxicity, a high ability to enhance the physical and operant working maintenance of animals, to accelerate its recovery in developed fatigue, in hyperthermia and hypoxia in particular. 2-(para-chlorobenzoylamine)adamantane (chlodantane) has the processes of a rapid-action adaptogenic agent by enhancing the resistance of animals to various physical and toxically chemical noxious agents. The two compounds have immunostimulating effects in secondary stress-induced immunodeficiencies whose mechanism of action is a membranous protective activity.
AuthorsI S Morozov, N V Klimova, S A Sergeeva, I A Ivanova, V G Barchukov, G I Kovalev, B M Piatin, N I Avdiunina
JournalVestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 3 Pg. 28-32 ( 1999) ISSN: 0869-6047 [Print] Russia (Federation)
Vernacular TitleProizvodnye adamantana, povyshaiushchie ustoĭchivost' organizma k ékstremal'nym vozdeĭstviiam.
PMID10222828 (Publication Type: Comparative Study, Journal Article, Review)
Chemical References
  • Psychotropic Drugs
  • Amantadine
  • bromantane
  • Adamantane
Topics
  • Adamantane (analogs & derivatives)
  • Amantadine (analogs & derivatives, pharmacology)
  • Animals
  • General Adaptation Syndrome (prevention & control)
  • Humans
  • Mice
  • Psychotropic Drugs (pharmacology)
  • Rats
  • Stress, Psychological (drug therapy)

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