HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism.

Abstract
Thirty-four patients with moderate-severe hirsutism were enrolled in this study. The patients received 125 mg/day flutamide for a period of 6 months. Hirsutism score and hormone parameters including FSH, LH, T, free T, androstenedione (A), DHEAS, PRL and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and repeated at every three-monthly intervals. Hirsutism greatly improved during flutamide therapy, and the hirsutism score significantly decreased at month 3 and 6 from a mean (+/-SD) of 17.19+/-4.55 to 10.75+/-3.84 (p<0.001) and 17.19+/-4.55 to 5.91+/-2.53 (p<0.001), respectively. A significant reduction in hirsutism score (mean%+/-SD) as compared to baseline was observed at 3 months (37.78+/-13.30, p<0.001) and at 6 months (65.47+/-13.49, p<0.001). No significant changes in the levels of hormone and no serious side effects were observed in the patients. The lower dose flutamide, 125 mg/day, is a safe and cost-effective drug in the treatment of hirsutism. Lower dose flutamide may be used in place of high dose flutamide, 250 to 750 mg/day.
AuthorsI I Müderris, F Bayram
JournalJournal of endocrinological investigation (J Endocrinol Invest) Vol. 22 Issue 3 Pg. 165-8 (Mar 1999) ISSN: 0391-4097 [Print] Italy
PMID10219882 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Androgen Antagonists
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Androstenedione
  • Estradiol
  • Dehydroepiandrosterone Sulfate
  • Flutamide
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adolescent
  • Adult
  • Androgen Antagonists (administration & dosage, adverse effects, therapeutic use)
  • Androstenedione (blood)
  • Dehydroepiandrosterone Sulfate (blood)
  • Estradiol (blood)
  • Female
  • Flutamide (administration & dosage, adverse effects, therapeutic use)
  • Follicle Stimulating Hormone (blood)
  • Hirsutism (drug therapy)
  • Humans
  • Luteinizing Hormone (blood)
  • Prolactin (blood)
  • Sex Hormone-Binding Globulin (analysis)
  • Testosterone (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: