Abstract |
Thirty-four patients with moderate-severe hirsutism were enrolled in this study. The patients received 125 mg/day flutamide for a period of 6 months. Hirsutism score and hormone parameters including FSH, LH, T, free T, androstenedione (A), DHEAS, PRL and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and repeated at every three-monthly intervals. Hirsutism greatly improved during flutamide therapy, and the hirsutism score significantly decreased at month 3 and 6 from a mean (+/-SD) of 17.19+/-4.55 to 10.75+/-3.84 (p<0.001) and 17.19+/-4.55 to 5.91+/-2.53 (p<0.001), respectively. A significant reduction in hirsutism score (mean%+/-SD) as compared to baseline was observed at 3 months (37.78+/-13.30, p<0.001) and at 6 months (65.47+/-13.49, p<0.001). No significant changes in the levels of hormone and no serious side effects were observed in the patients. The lower dose flutamide, 125 mg/day, is a safe and cost-effective drug in the treatment of hirsutism. Lower dose flutamide may be used in place of high dose flutamide, 250 to 750 mg/day.
|
Authors | I I Müderris, F Bayram |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 22
Issue 3
Pg. 165-8
(Mar 1999)
ISSN: 0391-4097 [Print] Italy |
PMID | 10219882
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Androgen Antagonists
- Sex Hormone-Binding Globulin
- Testosterone
- Androstenedione
- Estradiol
- Dehydroepiandrosterone Sulfate
- Flutamide
- Prolactin
- Luteinizing Hormone
- Follicle Stimulating Hormone
|
Topics |
- Adolescent
- Adult
- Androgen Antagonists
(administration & dosage, adverse effects, therapeutic use)
- Androstenedione
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Estradiol
(blood)
- Female
- Flutamide
(administration & dosage, adverse effects, therapeutic use)
- Follicle Stimulating Hormone
(blood)
- Hirsutism
(drug therapy)
- Humans
- Luteinizing Hormone
(blood)
- Prolactin
(blood)
- Sex Hormone-Binding Globulin
(analysis)
- Testosterone
(blood)
|