Abstract | PURPOSE: To describe a potential association between male infertility and valproate (VPA) exposure. VPA has been implicated in the development of polycystic ovarian disease and subsequent menstrual and infertility problems in women with epilepsy. Infertility has been well described in population-based studies of persons with epilepsy. The low marital rates for men with epilepsy have previously been thought to play a major contributing role. METHODS: RESULTS:
Felbamate (FBM) was initiated and VPA discontinued for improved seizure control. Within 4 months, the couple conceived their second child. A seminal analysis revealed a sperm count of > 16 million, 50% motility, 78% viability, and 72% with abnormal structure. CONCLUSIONS: One must be cautious in extrapolating from a case report, but these findings strongly suggest a direct effect of VPA on spermatic structure and function.
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Authors | M S Yerby, G B McCoy |
Journal | Epilepsia
(Epilepsia)
Vol. 40
Issue 4
Pg. 520-1
(Apr 1999)
ISSN: 0013-9580 [Print] United States |
PMID | 10219283
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anticonvulsants
- Phenylcarbamates
- Propylene Glycols
- Valproic Acid
- Felbamate
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Topics |
- Adult
- Anticonvulsants
(adverse effects, therapeutic use)
- Drug Therapy, Combination
- Epilepsy
(drug therapy)
- Felbamate
- Female
- Humans
- Infertility, Male
(chemically induced, prevention & control)
- Male
- Phenylcarbamates
- Propylene Glycols
(therapeutic use)
- Sperm Count
(drug effects)
- Valproic Acid
(adverse effects, therapeutic use)
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