Preoperative plasma levels of prothrombin fragment 1 + 2 correlate with the risk of venous thrombosis after elective hip replacement.

Abstract

Better preoperative identification of those patients at high risk of developing a deep vein thrombosis (DVT) after hip surgery could reduce the incidence of this postoperative complication, which still occurs despite prophylaxis. One hundred fifty-nine patients undergoing elective total hip replacement and given anticoagulant prophylaxis, were investigated, looking for the presence of a hypercoagulable state, that represents one element of Virchow's triad predisposing to DVT. Plasma levels of three markers of coagulation activation, namely prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin III complexes (TAT) and D-dimer were measured using ELISA procedures and were correlated with the results of the postoperative phlebography. A high correlation (p < 0.001) between the preoperative plasma levels of F1 + 2 and the risk of postoperative venous thromboembolism was detected. The performance of TAT and D-dimer levels in predicting DVT was lower. These findings support the hypothesis that preoperative measurement of coagulation activation markers might be useful in predicting DVT following a total hip replacement.

• Authors: A Corradi, F Lazzaro, E Cofrancesco, M Cortellaro, F Ravasi, F Bertocchi
• Journal: Acta orthopaedica Belgica (Acta Orthop Belg) Vol. 65 Issue 1 Pg. 39-43 (Mar 1999) ISSN: 0001-6462 [Print] Belgium
• PMID: 10217000 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Peptide Fragments
• Prothrombin

Topics

• Adult
• Aged
• Aged, 80 and over
• Arthroplasty, Replacement, Hip (adverse effects)
• Biomarkers (analysis)
• Elective Surgical Procedures (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Peptide Fragments (blood)
• Postoperative Complications
• Prothrombin (analysis)
• Risk Factors
• Venous Thrombosis (etiology)