Abstract |
To evaluate the role of leukotriene B4 ( LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. Rats were given intraperitoneal injections of ONO-4057 or phosphate-buffered saline 24 h before the injection of NTS. These rats subsequently received equal doses of ONO-4057 or phosphate-buffered saline 3 h and 1, 2, 3, 4, 5, and 6 d later. Compared with the control groups, ONO-4057 treatment significantly reduced proteinuria and hematuria, suppressed the glomerular accumulation of monocytes/macrophages, and reduced the formation of crescentic glomeruli in a dose-dependent manner. These results suggest that LTB4 is responsible for the crescentic formations and renal dysfunction associated with NTS nephritis. The LTB4 receptor antagonist ONO-4057 may thus be beneficial in the treatment of crescentic glomerulonephritis.
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Authors | S Suzuki, T Kuroda, J I Kazama, N Imai, H Kimura, M Arakawa, F Gejyo |
Journal | Journal of the American Society of Nephrology : JASN
(J Am Soc Nephrol)
Vol. 10
Issue 2
Pg. 264-70
(Feb 1999)
ISSN: 1046-6673 [Print] United States |
PMID | 10215325
(Publication Type: Journal Article)
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Chemical References |
- Immune Sera
- Immunosuppressive Agents
- Phenylpropionates
- Receptors, Leukotriene B4
- ONO-LB 457
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Glomerulonephritis
(immunology, pathology, prevention & control, urine)
- Hematuria
(urine)
- Immune Sera
(immunology)
- Immunohistochemistry
- Immunosuppressive Agents
(pharmacology)
- Kidney Glomerulus
(drug effects, pathology)
- Male
- Phenylpropionates
(pharmacology)
- Proteinuria
(urine)
- Rats
- Rats, Inbred WKY
- Receptors, Leukotriene B4
(antagonists & inhibitors)
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