Effect of polyphenon-60 on the development of renal cell tumors in rats treated with N-ethyl-N hydroxyethylnitrosamine.

Abstract

Green tea consumed as a beverage in Asia contains polyphenols, which contain about a 15% mixture of catechins. The present paper reports the effect of polyphenon-60 (60% pure catechin) on the development of renal cell neoplasms in Wistar rats pretreated with N-ethyl-N-hydroxyethylnitrosamine (EHEN): 0.1% polyphenon-60 in block diet was given over a period of 30 weeks while EHEN was given in drinking water for 2 weeks. The results appears to show a tendency for green tea catechins (GTC) to decrease the incidence of renal cell tumors greater than 3 mm in diameter in Wistar rats but not tumors that are less than 3 mm in diameter. Polyphenon-60 did not affect EHEN initiation in the kidneys of rats. It is postulated that free radicals induced by EHEN may be suppressed by GTC, resulting in a lowering of the tendency for tumor growth.

• Authors: N Yoshioka, Y Hiasa, M Cho, Y Kitahori, K Hirao, N Konishi, S Kuwashima
• Journal: Cancer letters (Cancer Lett) Vol. 136 Issue 1 Pg. 79-82 (Feb 08 1999) ISSN: 0304-3835 [Print] Ireland
• PMID: 10211943 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Tea
• N-ethyl-N-hydroxyethylnitrosamine
• Diethylnitrosamine
• Catechin

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Carcinogens (antagonists & inhibitors)
• Carcinoma, Renal Cell (chemically induced, pathology, prevention & control)
• Catechin (pharmacology)
• Diethylnitrosamine (analogs & derivatives, antagonists & inhibitors)
• Kidney Neoplasms (chemically induced, pathology, prevention & control)
• Male
• Rats
• Rats, Wistar
• Tea