Elevated parathyroid hormone 44-68 and osteoarticular changes in patients with genetic hemochromatosis.

Abstract

OBJECTIVE:

To determine whether the osteoarticular changes associated with genetic hemochromatosis could be explained by metabolic parathyroid hormone (PTH) disorders.

METHODS:

The study involved 210 patients with liver iron overload syndromes. Osteoarticular changes were numerically scored as the number of damaged joints. PTH 1-84 and 44-68 were assayed.

RESULTS:

An increase in serum PTH 44-68 levels was found in one-third of untreated patients who had no calcium or PTH 1-84 abnormalities. Serum PTH 44-68 levels correlated positively with serum ferritin levels. In multivariate analyses, the number of affected joints correlated positively with age, serum PTH 44-68 levels, and serum ferritin levels.

CONCLUSION:

Liver iron overload syndromes, especially genetic hemochromatosis, are associated with elevated circulating levels of PTH fragments containing the 44-68 region, which appears to play a role in osteoarticular changes. This increase seems to be a consequence of iron overload.

• Authors: Y Pawlotsky, P Le Dantec, R Moirand, P Guggenbuhl, A M Jouanolle, M Catheline, J Meadeb, P Brissot, Y Deugnier, G Chalès
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 42 Issue 4 Pg. 799-806 (Apr 1999) ISSN: 0004-3591 [Print] United States
• PMID: 10211896 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Parathyroid Hormone
• Peptide Fragments
• Transferrin
• parathyroid hormone (44-68)
• Ferritins
• Iron

Topics

• Adolescent
• Adult
• Aged
• Chondrocalcinosis (complications, metabolism, pathology)
• Female
• Ferritins (blood)
• Hemochromatosis (complications, genetics, metabolism)
• Humans
• Iron (metabolism)
• Joints (metabolism, pathology)
• Liver (metabolism)
• Male
• Middle Aged
• Multivariate Analysis
• Parathyroid Hormone (blood)
• Peptide Fragments (blood)
• Transferrin (metabolism)