Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats.

Abstract

We investigated the protective effect of chronic treatment with AE0047, a dihydropyridine-type calcium channel blocker, on vascular endothelial abnormalities in stroke-prone spontaneously hypertensive rats (SHRSP). Ten-week repeated antihypertensive treatment with AE0047 inhibited blood pressure elevation and improved endothelium-dependent relaxation in response to acetylcholine in aorta isolated from SHRSP. Furthermore, the abnormal production of prostaglandin I2 and thromboxane A2 in the aorta was normalized to a level equivalent to that in Wistar-Kyoto rats. These results suggest that chronic treatment with AE0047 exerts protective effects against endothelial abnormalities associated with the development of hypertension.

• Authors: M Nishikawa, Y Kubo, H Kido, T Nakayama, N Nakamura
• Journal: General pharmacology (Gen Pharmacol) Vol. 32 Issue 3 Pg. 299-305 (Mar 1999) ISSN: 0306-3623 [Print] England
• PMID: 10211583 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Calcium Channel Blockers
• Dihydropyridines
• Prostaglandins
• Protective Agents
• AE0047

Topics

• Animals
• Antihypertensive Agents (therapeutic use)
• Aorta (drug effects, metabolism)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Cerebrovascular Disorders (etiology)
• Dihydropyridines (pharmacology, therapeutic use)
• Endothelium, Vascular (drug effects)
• Heart Rate (drug effects)
• Hypertension (drug therapy)
• Male
• Prostaglandins (biosynthesis)
• Protective Agents (therapeutic use)
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY
• Vasoconstriction (drug effects)
• Vasodilation (drug effects)