Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts.

Abstract

We synthesized a series of thienopyrimidine derivatives and examined their cytotoxic effects on several cell lines. One of the derivatives, NSL-1406, was shown to exert potent cytotoxic effects on leukemia cell line including P388 cells and J774 cells. It was also inhibitory on mouse osteoclasts and suppressed the in vitro bone resorption by osteoclasts at nanomolar concentrations.

• Authors: J Katada, K Iijima, M Muramatsu, M Takami, E Yasuda, M Hayashi, M Hattori, Y Hayashi
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 9 Issue 6 Pg. 797-802 (Mar 22 1999) ISSN: 0960-894X [Print] England
• PMID: 10206538 (Publication Type: Comparative Study, Journal Article)

Chemical References

• NSL 1406
• Pyrimidines

Topics

• Animals
• Cell Count
• Cell Line
• Dose-Response Relationship, Drug
• Inhibitory Concentration 50
• Leukemia P388 (drug therapy)
• Leukocytes (drug effects)
• Mice
• Models, Chemical
• Osteoclasts (drug effects)
• Pyrimidines (chemistry, pharmacology)
• Structure-Activity Relationship
• Tumor Cells, Cultured