Effects of adenosine receptor agents on the expression of morphine withdrawal in mice.

Abstract

Effects of different doses of adenosine receptor agonists and antagonists on naloxone-induced jumping and diarrhea in morphine-dependent mice were studied. The adenosine A1 receptor agonists, N6-cyclohexyladenosine (CHA: 0.1, 0.25 and 0.5 mg kg(-1)) and R-isomer of N6-phenylisopropyladenosine (R-PIA: 0.1, 0.3 and 1 mg kg(-1)), decreased jumping and diarrhea induced by naloxone in morphine-dependent mice. The adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX: 0.3-9 mg kg(-1)), increased jumping but decreased diarrhea. The adenosine A2 receptor agonist, 5'-(N-cyclopropyl)-carboxamidoadenosine (CPCA), decreased jumping and diarrhea. However, the adenosine A2 receptor antagonist, 3,7-dimethyl-1-propargylxanthine (DMPX: 0.5 and 1 mg kg(-1)), did not elicit any response in this respect. DPCPX (0.3 and 3 mg kg(-1)), decreased the inhibition of jumping and diarrhea induced by CHA (0.5 mg kg(-1)), while DMPX (0.5 and 1 mg kg(-1)), decreased the inhibition of diarrhea induced by CPCA (0.1 mg kg(-1)). It is concluded that jumping induced by naloxone in morphine-dependent mice may be modified by the adenosine A receptor mechanism(s) and diarrhea induced by the opioid receptor antagonist could be mediated by the adenosine A1 and A2 receptors.

• Authors: M R Zarrindast, B Naghipour, F Roushan-zamir, B Shafaghi
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 369 Issue 1 Pg. 17-22 (Mar 12 1999) ISSN: 0014-2999 [Print] Netherlands
• PMID: 10204676 (Publication Type: Journal Article)

Chemical References

• Narcotic Antagonists
• Narcotics
• Purinergic P1 Receptor Agonists
• Purinergic P1 Receptor Antagonists
• Xanthines
• N-(1-methyl-2-phenylethyl)adenosine
• N(6)-cyclohexyladenosine
• Naloxone
• N-cyclopropyl adenosine-5'-carboxamide
• 3,7-dimethyl-1-propargylxanthine
• Morphine
• 1,3-dipropyl-8-cyclopentylxanthine
• Adenosine
• Theobromine

Topics

• Adenosine (analogs & derivatives, pharmacology)
• Analysis of Variance
• Animals
• Behavior, Animal (drug effects)
• Diarrhea (chemically induced, prevention & control)
• Male
• Mice
• Mice, Inbred Strains
• Morphine (adverse effects)
• Morphine Dependence (physiopathology)
• Naloxone (pharmacology)
• Narcotic Antagonists (pharmacology)
• Narcotics (adverse effects)
• Purinergic P1 Receptor Agonists
• Purinergic P1 Receptor Antagonists
• Substance Withdrawal Syndrome (etiology, physiopathology, prevention & control)
• Theobromine (analogs & derivatives, pharmacology)
• Xanthines (pharmacology)