HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Noradrenaline synthesis during the first week of life and development of inherited stress-induced arterial hypertension in rats].

Abstract
Increasing of the noradrenaline synthesis with daily i.p. administration of synthetic noradrenaline precursor DL-Threo on the 21-25th day of life of the rats with inherited stress-induced arterial hypertension (ISIAH) resulted in a drop of basal and stress-induced blood pressure in adult animals with no changes in response of the hypothalamic-pituitary-adrenocortical system (HPAS). Reduction of the noradrenaline synthesis with daily i.p. administration of dopamine-hydroxylase inhibitor FLA-57 in 21-25th day old Wistar rats induced no arterial hypertension in adults but decreased their adrenocortical response to emotional stress. Noradrenaline deficit in the brain structures on the 4th week of life in rats seems to be associated with arterial hypertension only in presence of genetic defect determining this pathology. Changes in adult HPAS function due to shortage of noradrenaline in the brain in the end of the 1st month of life do not depend on hypertension.
AuthorsL N Maslova, V V Bulygina, A L Markel'
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 84 Issue 11 Pg. 1207-13 (Nov 1998) ISSN: 0869-8139 [Print] Russia (Federation)
Vernacular TitleVozdeĭstviia na sintez noradrenalina na 4-ĭ nedele zhizni i razvitie nasledstvennoĭ indutsiruemoĭ stressom arterial'noĭ gipertenzii u krys.
PMID10204164 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Azepines
  • Enzyme Inhibitors
  • 4-methyl-1-homopiperazinedithiocarboxylic acid
  • Dopamine beta-Hydroxylase
  • Droxidopa
  • Norepinephrine
Topics
  • Animals
  • Azepines (pharmacology)
  • Blood Pressure
  • Dopamine beta-Hydroxylase (antagonists & inhibitors)
  • Droxidopa (pharmacology)
  • Enzyme Inhibitors (pharmacology)
  • Hypertension (genetics, metabolism, physiopathology)
  • Norepinephrine (biosynthesis, deficiency)
  • Rats
  • Rats, Wistar
  • Species Specificity
  • Stress, Psychological (metabolism, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: