Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice.

Abstract

We evaluated the antinociceptive effect of Gosha-jinki-gan, a Kampo medicine including processed Aconiti tuber, and its mechanism in streptozotocin-induced diabetic mice. Gosha-jinki-gan (0.1-1.0 g/kg, p.o.) showed a more potent antinociceptive effect in diabetic mice than in non-diabetic mice. The antinociceptive effect of Gosha-jinki-gan (0.3 g/kg, p.o.) in diabetic mice was inhibited by administration of either anti-dynorphin antiserum (5 microg, i.t.) or nor-binaltorphimine (10 mg/kg, s.c.), a kappa-opioid antagonist. The antinociceptive activity of Gosha-jinki-gan (0.3, 1.0 g/kg, p.o.) was decreased by excluding processed Aconiti tuber. Furthermore, the antinociceptive effect of processed Aconiti tuber (0.03, 0.1 g/kg, p.o.) was also shown to be enhanced in diabetic mice. These results suggest that the increased antinociceptive effect of Gosha-jinki-gan in diabetic mice is partly derived from the action of processed Aconiti tuber and that it is based on stimulation of spinal kappa-opioid receptors via dynorphin release. Gosha-jinki-gan was considered useful for treating painful diabetic neuropathy.

• Authors: Y Suzuki, K Goto, A Ishige, Y Komatsu, J Kamei
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 79 Issue 2 Pg. 169-75 (Feb 1999) ISSN: 0021-5198 [Print] Japan
• PMID: 10202852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Drugs, Chinese Herbal
• Immune Sera
• gosha-jinki-gan
• Dynorphins

Topics

• Analgesics (pharmacology, therapeutic use)
• Animals
• Diabetes Mellitus, Experimental (complications)
• Diabetic Neuropathies (drug therapy)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Dynorphins (antagonists & inhibitors, immunology)
• Immune Sera (pharmacology)
• Male
• Mice
• Pain Measurement
• Time Factors