HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tremorlytic activity of budipine in Parkinson's disease.

Abstract
To objectively quantify the tremorlytic activity of budipine in Parkinson's disease (PD), we performed long-term tremor recordings in addition to the Columbia University Rating Scale (CURS) in a subset of patients (n = 14) who enrolled in a multicenter, double-blind, placebo-controlled study. Tremor occurrence improved in the budipine group (n = 7) from 24.7 +/- 15.5% to 14.8 +/- 14.5% (p < 0.05). Tremor intensity decreased from 9.1 +/- 2.5 (signal-to-noise ratio) to 7.2 +/- 1.6. The CURS sum score improved from 5.7 to 3.0 in the budipine group, whereas there was only a small improvement in the placebo group (from 7.1 to 5.5). These data suggest that budipine is an effective tremorlytic agent in PD and that it may be used as an alternative to anticholinergics.
AuthorsS Spieker, R Eisebitt, S Breit, H Przuntek, D Müller, T Klockgether, J Dichgans
JournalClinical neuropharmacology (Clin Neuropharmacol) 1999 Mar-Apr Vol. 22 Issue 2 Pg. 115-9 ISSN: 0362-5664 [Print] United States
PMID10202609 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Antiparkinson Agents
  • Piperidines
  • Placebos
  • Bromocriptine
  • Levodopa
  • budipine
Topics
  • Aged
  • Antiparkinson Agents (adverse effects, therapeutic use)
  • Bromocriptine (therapeutic use)
  • Double-Blind Method
  • Electromyography
  • Female
  • Humans
  • Levodopa (therapeutic use)
  • Male
  • Middle Aged
  • Parkinson Disease (drug therapy, physiopathology)
  • Piperidines (adverse effects, therapeutic use)
  • Placebos
  • Tremor (physiopathology, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: