The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures.

Abstract

PURPOSE:

This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures.

PATIENTS AND METHODS:

Twelve patients with a history of edema after dental procedures were administered danazol (600 mg/d) 4 days preoperatively and 4 days postoperatively. The serum levels of complement components were determined preoperatively and postoperatively as well as at 6, 12 and 24 hours in six patients.

RESULTS:

None of the 12 patients developed angioneurotic edema. The serum levels of the complement components were decreased immediately after surgery and returned to normal within 24 hours.

CONCLUSION:

The short-term prophylactic use of danazol in patients with hereditary angioedema undergoing oral surgery is an effective preventive measure.

• Authors: H Farkas, L Gyeney, E Gidófalvy, G Füst, L Varga
• Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 57 Issue 4 Pg. 404-8 (Apr 1999) ISSN: 0278-2391 [Print] United States
• PMID: 10199492 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Estrogen Antagonists
• Danazol

Topics

• Adult
• Angioedema (blood, prevention & control)
• Danazol (administration & dosage)
• Dental Care for Chronically Ill (methods)
• Estrogen Antagonists (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Postoperative Care
• Preoperative Care
• Surgery, Oral
• Time Factors