Preventive effects of a mixed disulphide from dithiocarbamate and N-acetylcysteine on the genotoxicity of N-nitrosodiethylamine.

Abstract

A mixed disulphide model compound, S-(N,N-diethyldithiocarbamoyl)-N-acetylcysteine (AC-DDTC), prepared from diethyldithiocarbamate and N-acetylcysteine, was investigated for protective effects against the genotoxicity of the environmental carcinogen N-nitrosodiethylamine (NDEA). AC-DDTC was found to be a potent inhibitor of genotoxicity induced by NDEA. The mutagenicity of NDEA to Salmonella typhimurium was inhibited by 70% at 3.2 micromol AC-DDTC per plate and the effect was dose-dependent. In the chromosome aberration assay, NDEA elicited a significant increase in the number of aberrant cells. Pretreatment with AC-DDTC suppressed the chromosome-damaging effect of NDEA. The micronucleus-inducing capacity of NDEA was reduced by 32% by treatment with AC-DDTC at 1.5 mmol kg(-1). These results suggest that AC-DDTC might have a role to play in reducing the risk of cancer induced by NDEA.

• Authors: B H Lee, S J Lee
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 51 Issue 1 Pg. 105-9 (Jan 1999) ISSN: 0022-3573 [Print] England
• PMID: 10197426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimutagenic Agents
• Mutagens
• S-(N,N-diethyldithiocarbamoyl)-N-acetylcysteine
• Diethylnitrosamine
• Acetylcysteine

Topics

• Acetylcysteine (analogs & derivatives, pharmacology)
• Animals
• Antimutagenic Agents (pharmacology)
• Chromosome Aberrations (genetics)
• Cricetinae
• Cricetulus
• Diethylnitrosamine (toxicity)
• Drug Interactions
• Male
• Mice
• Mice, Inbred ICR
• Micronucleus Tests
• Mutagenicity Tests
• Mutagens (toxicity)
• Salmonella typhimurium (genetics)