The effect of cetirizine on symptoms and signs of nasal polyposis.

Abstract	Forty-five patients with residual or recurrent nasal polyposis after ethmoidectomy were treated with either cetirizine at twice the daily recommended (20 mg) dose or placebo for three months. The number and size of polyps remained unchanged during the study period. Cetirizine was found to reduce nasal sneezing and rhinorrhoea effectively. The drug also had a beneficial effect on nasal obstruction in the latter part of the study. The side effects of 20 mg (double the recommended daily adult dose) of cetirizine were few and comparable to placebo.
Authors	R Haye, J P Aanesen, B Burtin, F Donnelly, C Duby
Journal	The Journal of laryngology and otology (J Laryngol Otol) Vol. 112 Issue 11 Pg. 1042-6 (Nov 1998) ISSN: 0022-2151 [Print] England
PMID	10197141 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Allergic Agents Histamine H1 Antagonists Cetirizine
Topics	Adult Aged Anti-Allergic Agents (therapeutic use) Cetirizine (therapeutic use) Double-Blind Method Drug Administration Schedule Female Histamine H1 Antagonists (therapeutic use) Humans Male Middle Aged Nasal Mucosa (drug effects) Nasal Polyps (drug therapy)

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