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The first combined vaccine against hepatitis A and B: an overview.

Abstract
Hepatitis A and B infections are prevalent world-wide and are a significant cause of morbidity and mortality. A vaccine providing dual protection against hepatitis A and B is now available (Twinrix, SmithKline Beecham Biologicals). Six pivotal vaccine trials, involving 843 healthy adults, aged between 17 and 60 years and vaccinated following a 0, 1, 6 month schedule are discussed. At month 2 more than 99% of the vaccinees were seropositive for anti-HAV and 84% were protected against hepatitis B. The third dose induced a 12-fold increase in geometric mean titres (GMTs) to 5404 mIU/ml. One month after completion of the vaccination course nearly all vaccinees had protective titres against hepatitis B with a GMT of 4818 mIU/ml. Long term follow-up data until month 48 is available for two studies. At month 48 all 129 vaccinees sampled were still positive for anti-HAV antibodies and > 95% were still protected against hepatitis B. The combined hepatitis A and B vaccine Twinrix proves to be consistently safe, well tolerated and highly immunogenic and compares well with serological responses reached with monovalent vaccines. This combined hepatitis A and B vaccine offers more convenience, potentially better compliance and lower administration costs.
AuthorsS Thoelen, P Van Damme, A Leentvaar-Kuypers, G Leroux-Roels, M Bruguera, P C Frei, V Bakasenas, A Safary
JournalVaccine (Vaccine) Vol. 17 Issue 13-14 Pg. 1657-62 (Mar 26 1999) ISSN: 0264-410X [Print] ENGLAND
PMID10194819 (Publication Type: Journal Article)
Chemical References
  • Hepatitis A Vaccines
  • Hepatitis Antibodies
  • Hepatitis B Vaccines
  • Vaccines, Combined
  • Viral Hepatitis Vaccines
Topics
  • Adolescent
  • Adult
  • Clinical Trials as Topic
  • Female
  • Follow-Up Studies
  • Hepatitis A Vaccines
  • Hepatitis Antibodies (blood)
  • Hepatitis B Vaccines (immunology)
  • Humans
  • Male
  • Middle Aged
  • Vaccination
  • Vaccines, Combined (immunology)
  • Viral Hepatitis Vaccines (immunology)

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