Abstract | BACKGROUND: METHODS: Seven patients with biopsy-proved bronchioloalveolar carcinoma and no evidence of extrapulmonary disease received transplants of either one or two cadaveric lungs. At transplantation, all native lung tissue was removed and replaced with a donor lung or lungs. The patients received the usual post- transplantation care given at the institution. RESULTS: Four of the seven patients had recurrent bronchioloalveolar carcinoma within the donor lungs; the recurrences appeared from 10 to 48 months after transplantation. All recurrences were limited to the donor lungs. Histologic and molecular analyses showed that the recurrent tumors in three patients originated from the recipients of the transplants. CONCLUSIONS:
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Authors | R I Garver Jr, G L Zorn, X Wu, D C McGiffin, K R Young Jr, N B Pinkard |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 340
Issue 14
Pg. 1071-4
(Apr 08 1999)
ISSN: 0028-4793 [Print] United States |
PMID | 10194236
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Adenocarcinoma, Bronchiolo-Alveolar
(pathology, surgery)
- Adult
- Female
- Humans
- Lung Neoplasms
(pathology, surgery)
- Lung Transplantation
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Treatment Outcome
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