HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effect of arpenal on the EMG-potentials of the anterior tibial muscle in cats during acute phosdrine poisoning].

Abstract
The authors examined the changes in the nerve-muscular conductivit occuring after acute poisoning with phosdrine and treatment with arpenal and oximic reacytivators of HE-toxogonine and TMB-4 on 20 cats, anesthethised with urethane and atropine protection under the conditions of artificinal respiration. They found that there was a total nerve-muscular block cessation of the mediation in the myoneural synaptic zones, characterized by complete cessation also of the induced electrical responses after single and serial stimuli, during acute intoxications with phosdrine, used in lethal doses of 300 mg/kg intramuscularly. After treatment with H-cholinolitics (arpenal) there was a quick recovery of the muscle contractions as well as of the evoked myopotentials after stimulation with single electric stimuli. In contrast to the oximnic reactivators of He (toxogonine, TMB-4) during serial electric stimuli (10,20 and 30 per second after treatment with arpenal there was a quick contraction only after the first stimulus, after which a progresive weakening of the induced electric myopotentials followed till the appearence of a total nerve-muscular block. This phenomenon was explained by the lack of reactivating properties of H-cholinolitics to HE, inhibited by FOV.
AuthorsD Mashkova
JournalEksperimentalna meditsina i morfologiia (Eksp Med Morfol) Vol. 15 Issue 4 Pg. 237-41 ( 1976) ISSN: 0367-0643 [Print] Bulgaria
Vernacular TitleVliianie na arpenala vurkhu EMG-potentsialite na predniia tibialen muskul na kotki pri ostrite intoksikatsii s fosdrin
PMID1017412 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Diphenylacetic Acids
  • Insecticides
  • Neuromuscular Blocking Agents
  • Mevinphos
Topics
  • Acute Disease
  • Animals
  • Cats
  • Diphenylacetic Acids (pharmacology)
  • Electromyography
  • Female
  • Insecticides (poisoning)
  • Male
  • Mevinphos (poisoning)
  • Muscles (physiopathology)
  • Neuromuscular Blocking Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: