Of two groups of rats, one received a normal diet and the other a high fat diet for 5 weeks. The effects of
oxythioquinox, administred at diet concentration of 200, 400 and 800 mg/kg, of fresh food are studied on
weight gain, food and calorie intake and on the weight and composition of various organs. Growth, food and calorie intake are diminished in relation to
oxythioquinox concentration in the diet. There exist an interaction between the fat content of the diet and the toxicity of
oxythioquinox. The decrease of the efficiency of calorie by
oxythioquinox indicates a perturbation of the rats metabolism. An increase in the weight of the liver is observed with a significant interaction between the fat concentration and the
oxythioquinox with the results expressed in weight of organ per 100 g
body weight. There is an increase in the degree of the water content of the animals liver with normal fat diet. In the case of a high fat diet there is an increase of
cholesterol and
fatty acid content. In all case, the variations are more strongly marked in relation to the
oxythioquinox concentration of the diet and at the same concentration, the high fat diet is more effective that the normal diet. There is an interaction between the
lipids in the diet and the
oxythioquinox and this interaction indicates, an accentuation of the effects of
oxythioquinox by
lipids of the diet.